Dicamba tolerant soybeans, marketed under the trade name Roundup Ready 2 Xtend Soybeans are again available to Maryland growers for the 2018 growing season. This line of soybeans combines previous Roundup Ready technology with tolerance to the herbicide dicamba. While this new dicamba tolerance may be useful in combatting certain tough-to-control weeds including marestail and palmer amaranth, use caution when applying dicamba. Applications of dicamba may cause problems due to the sensitivity of certain crops to the herbicide. Exposure can occur due to drift, volatility, or a non-target application. This report provides recommendations for using new dicamba-tolerant technologies.